Pharmaceutical Industry

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Featured Pharmaceutical Industry articles

$Diagram showing roller compaction ribbon solid fraction governed by mass feed rate, nip angle and roll force$
Roller Compaction Ribbon Solid Fraction: Why the Same Roll Force Can Produce Different Granules
Two lots that pass the same incoming flowability spec can still granulate differently after roller compaction. The reason usually traces to ribbon density, which responds to roll force, gap width, and feed screw speed as an interacting set, not to roll pressure in isolation.
Fluidized Bed Processing in Powder Technology: Granulation, Coating, and Drying Through a Powder Behavior Lens
Geldart classification, minimum fluidization velocity, bubble dynamics, droplet-to-particle size ratio, and permeability all determine whether a fluidized bed process delivers controlled granule growth, uniform coating, or consistent drying at production scale.
Spray Drying 4.0: Real-Time PAT, AI Process Control, and What Engineers Actually Gain
Process analytical technology combined with machine learning is changing residual moisture control and yield prediction in pharmaceutical and food spray drying. The gains are real but bounded, and the off-line test panel has not been replaced.
Poorly Soluble APIs: How Surface Contact Shapes Dissolution and Bioavailability
Poorly soluble APIs now represent the majority of the pharmaceutical development pipeline. Dissolution and oral bioavailability are determined by molecular solubility, surface wetting behavior, solid-state stability, and how the formulation interacts with the GI environment from first contact onward. Amorphous dispersions, lipid systems, nanocrystals, and co-crystals each rely on different surface mechanisms to deliver their intended advantage.
The Search for Universal Dust Explosivity Criteria
Universal dust explosivity criteria fail because explosibility depends on dispersion, turbulence, ignition, and confinement. ASTM International E1226 characterizes a specific sample under defined test conditions; it does not predict every plant scenario. Use a Dust Hazard Analysis and representative testing to set your safe operating envelope. Table of contents [...]