Co-processing engineers particle morphology, density, and surface structure into a single composite excipient particle. Flow function and compactibility testing show what that buys formulators on continuous direct compression lines, and where it does not.
Poorly soluble APIs now represent the majority of the pharmaceutical development pipeline. Dissolution and oral bioavailability are determined by molecular solubility, surface wetting behavior, solid-state stability, and how the formulation interacts with the GI environment from first contact onward. Amorphous dispersions, lipid systems, nanocrystals, and co-crystals each rely on different surface mechanisms to deliver their intended advantage.
Packing density and powder flow rarely align naturally. [...]
Nano spray drying creates submicron powders from fragile [...]
Particle shape plays a critical role in the behavior [...]
Particle engineering is an emerging field impacting multiple [...]
Functional powder design plays a fundamental role [...]
Core particle engineering techniques like fluid bed agglomeration, [...]
Particle engineering is the golden goose of powder [...]
